OPTIMAL PARAMETERS CULTIVATION RABIES VIRUS STRAIN «CVS-11»
Keywords:
CVS-11, BHK-21, cell culture, monolayer, virus, zoonosis, rabies, passage, vaccine, inactivation, suspension, titration, antibody, antigen.Abstract
One of the urgent problems of veterinary biotechnology, which requires a clear solution to the technological production of vaccines (selection of strains, adaptation to growth, growing methods, biological products) as a domestic product in agriculture. When choosing a vaccine, special attention is paid to the safety of the drug and the duration of immunity in animals. For the production of vaccines, a strain of the virus having high immunogenic properties is required, which are also capable of retaining these properties during periods of cultivation and storage. To obtain an inactivated vaccine, various inactivants are used and the optimal condition for inactivation is selected. In such cases, the virus should completely lose its infectious properties and increase antigenicity. The above problems are relevant and are a key prerequisite for research on the development of technology for the production of rabies vaccines.
