New complex feed additive based on natural compounds with immunomodulating Properties

Abstract

Background and Aim. Natural feed additives that stimulate the innate resistance of animals will allow us to obtain ecologically clean meat and dairy products. The objective of this study was to evaluate physiological and biochemical efficiency of new complex feed additives through experi mental research.

Materials and Methods. The study was conducted on white laboratory rats of the Spraque Dawley line, divided into three groups - control group and two experimental groups receiving the feed additive. For comparison, our previously developed feed additive was used. The new additive includes bentonite and chlorella in addition to KI and selenium, which were incorporated using our new technology. Over a 21day study period, we analyzed blood lymph circulation, cellular and bio-chemical composition of blood and lymph, humoral immunity and oxidative activity in the blood. Supplementation with feed additive increased the protein content in the diet.

Results. The use of the new complex feed additive had a positive effect on the cardiovascular and lymphatic systems, modulated protein, carbohydrate and fat metabolism in the body, and pro-moted weight gain in animals. Taking the feed additive led to increased enzymatic activity as well as higher levels of protein, glucose, and lipids in the blood. The new feed additive demonstrated strong adsorption and antioxidant properties, reducing toxic effects in the body, participating in the inactivation of free radicals, protecting cell membranes, and enhancing energy expenditure which contributed to muscle mass gain.

Conclusion. The feed additive physiologically increased leukocytes, lymphocytes, and immunoglobulins in the blood and lymph. The new additive is high-calorie, possesses antioxidant and adaptogenic effect, maintains a balance of biochemical and oxidative processes, and most im portantly, has immunomodulatory properties - it enhances humoral and cellular immunity and can be recommended as a safe and effective dietary supplement to the daily diet of farm animals.