THE INFLUENCE OF BCG VACCINE TO THE CALVES‘S SKIN AFTER ADMINISTRATION
Keywords:
tuberculosis, electronic microscope, vaccine, BCG, pharenchyma.Abstract
The article presents the results of a study on calves after application of BCG vaccine. in the experiment, the calves of the Kazakh white breeds, 1-2 months of age. Using electron microscopy allowed establishing pronounced ultrastructural changes in the organism of calves immunized with BCG vaccine. They are characterized by: the destruction of the muscle fibers of the dermis and the appearance of necrotic detritus; macrophage reaction followed fibrotization tissue at the injection site; destruction of mitochondria in hepatocytes and epithelial tubules uriniparous; swelling of podocytes in renal vascular glomeruli. and also develop less serious violations: serous edema, partial fragmentation of striated fibers in the tissue at the site of these biologics, swelling of mitochondria with cristae fuzzy pattern in epithelial cells of the liver and kidneys.
